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KMID : 0366220150500010040
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Korean Journal of Hematology
2015 Volume.50 No. 1 p.40 ~ p.45
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SOCS1 and SOCS3 are expressed in mononuclear cells in human cytomegalovirus viremia after allogeneic hematopoietic stem cell transplantation
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Shin Seung-Hwan
Lee Ji-Yoon
Lee Tae-Hyang
Park So-Hye
Yahng Seung-Ah
Yoon Jae-Ho
Lee Sung-Eun
Cho Byung-Sik
Lee Dong-Gun
Kim Yoo-Jin
Lee Seok
Min Chang-Ki
Cho Seok-Goo
Kim Dong-Wook
Lee Jong-Wook
Min Woo-Sung
Park Chong-Won
Kim Hee-Je
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Abstract
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Background: The expression of the SOCS genes in cytomegalovirus (CMV) viremia after hematopoietic stem cell transplantation (HSCT) remains largely unexplored.
Methods: Using quantitative RT-PCR of mononuclear cells, we conducted pairwise comparison of SOCS1 and SOCS3 expression levels among a healthy donor group (N=55), a pre-HSCT group (N=17), and the recipient subgroup (N=107), which were divided according to the occurrence of CMV viremia and acute graft-versus-host disease (aGVHD).
Results: Compared to that in the healthy donor group, SOCS1 expression was higher in the CMV+subgroup, especially in the CMV+GVHD- group, but decreased in the other subgroups. When compared to the expression in the pre-HSCT group, SOCS1 expression was significantly higher in the CMV+ subgroup, especially in the CMV+GVHD+ subgroup. Meanwhile, compared to that in the healthy donor group, SOCS3 expression was significantly lower in all other groups. The CMV-GVHD- subgroup showed significantly lower SOCS3 expression compared to the CMV+ subgroup, the CMV+GVHD+ subgroup, and the CMV+GVHD- subgroup.
Conclusion: We report differential expression of SOCS genes according to CMV viremia with acute GVHD occurrence after HSCT, suggesting that regulation of SOCS expression is associated with CMV viremia.
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KEYWORD
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Suppressor of cytokine signaling (SOCS) 1 and 3, Cytomegalovirus (CMV) viremia, Quantitative real-time PCR, Allogeneic HSCT, GVHD
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